KEGG-based disease-drug-variant network research. Connects diseases to causal genes, drugs to molecular targets, and variants to pathways using KEGG's editorially curated databases (KEGG Disease, Drug, Network, Variant, Pathway). Use for drug repurposing via shared pathways, mechanistic disease-gene-drug networks, and pathway-based target discovery. Distinguishes direct (binding) vs indirect (pathway co-membership) drug-target relationships.

Generate comprehensive disease research reports covering genetics (causal genes, GWAS, OMIM), pathways (Reactome, KEGG), drugs (existing therapies, repurposing candidates), clinical trials, epidemiology (prevalence, incidence), and phenotypes (HPO). Use for full disease overviews, comprehensive disease characterization, and orphan/rare-disease profiling.

Multi-omics integration — orchestrate per-layer analysis (transcriptomics, proteomics, epigenomics, genomics, metabolomics) then perform cross-omics correlation, multi-omics clustering, and pathway-level integration. Use for integrative systems-biology analysis, multi-modal disease characterization, and cross-omics biomarker discovery.

Inorganic chemistry, physical chemistry, and materials science — crystal structures, coordination chemistry, lattice parameters, thermodynamic properties, electronic structure. Use for unit cell volume calculations, coordination geometry, materials property estimation, and inorganic-mechanism reasoning. Complementary to tooluniverse-organic-chemistry.

Use when defining or modifying an MPS generation plan — explicit ordering of generators, checkpoints for cross-model reference resolution, forks for parallel branches, IncludePlan composition, conditional PlanContribution activation, ParameterEquals/ConceptListSelector fork selectors, and InitModelAttributes for targetFacet routing. Apply when working with @genplan models, the jetbrains.mps.lang.generator.plan language, attaching plans via DevKits or the Custom generation facet, or debugging cross-model mapping label resolution.

Creates a validation project for testing a specific vscode-cmake-tools pull request. Use this skill when asked to create a validation project, test a PR, validate a pull request, or set up a PR validation environment. The skill creates a structured project directory with documentation, metadata, and checklists for systematically validating PR changes.

get an env var, fetch a secret, missing env var, missing token/API key, load secrets from Infisical, infisical. Fetch secrets from the team's Infisical workspace into the shell environment so subsequent commands can use them.

Reviews vMCP code changes for known anti-patterns that make the codebase harder to understand or more brittle. Use when reviewing PRs, planning features, or refactoring vMCP code.

Finds flaky tests on the main branch by analyzing GitHub Actions failures, ranks them by frequency, and enters parallel plan mode to design deflake strategies. Use when you want to find and fix the flakiest tests.

Explore a codebase to find opportunities for architectural improvement, focusing on making the codebase more testable by deepening shallow modules. Use when user wants to improve architecture, find refactoring opportunities, consolidate tightly-coupled modules, or make a codebase more AI-navigable.

Browser automation, debugging, and performance analysis using Puppeteer CLI scripts. Use for automating browsers, taking screenshots, analyzing performance, monitoring network traffic, web scraping, form automation, and JavaScript debugging.

Pydantic v2 — data validation and settings management using Python type hints. Use when defining models, validators, serializers, field constraints, or pydantic-settings configuration.

caddy-security repository automation, Makefile targets, build/test/report workflows, caddy-authenticator profile login, and security local CLI administration. Use for standalone portal authentication, local-user, password, and API-key commands; repository scripts; local go-authcrunch replacement workflows; generated artifacts; or routing release tasks to release-and-versioning.

Create a Jira task in the LPD project through the REST API. Use when the user asks to create a Jira task or LPD task ticket.

Develop, debug, and deploy Apify Actors - serverless cloud programs for web scraping, automation, and data processing. Use when creating new Actors, modifying existing ones, or troubleshooting Actor code.

In-chat fallback for the Timeline Inspector Refine agent. Use when the user runs `/refine live`, asks to "refine live", "go live", or answer refine jobs — but ONLY when no persistent agent is wired (no `npx transitions-refine live`). Prefer `npx transitions-refine live` for run-and-forget (relay spawns agent per click, no idle credit burn). This skill long-polls the relay, posts suggestions, handles scan/apply jobs.

Map an unfamiliar repository before changing it. Use when a task crosses packages, public contracts, persistence, runtime wiring, or verification lanes and the owning architecture is not yet clear.

Adopt, configure, run, or troubleshoot compozy/releasepr in a consuming repository, including Actions, beta/stable/legacy plans, notes, dry-runs, and publication. Excludes pr-release internals and general versioning advice.

基于当前项目/代码生成各类文档，支持论文章节、项目梳理、重点问题、简历项目描述四种类型。当用户提到生成论文章节、项目梳理、技术难点、简历项目描述时使用。要给新同事看的上手文档（新人文档、架构文档、代码导读、onboarding）用 project-docs。

Transcribe audio via OpenAI Audio Transcriptions API (Whisper).