This skill should be used when the user asks to "run initial analysis", "analyze single-cell data", "QC my data", "run bioinformatics pipeline", "generate analysis report", "explore my dataset", "do exploratory data analysis", "initial data analysis", or needs to perform quality control, dimensionality reduction, clustering, or marker analysis on single-cell biology data (CyTOF, scRNA-seq, flow cytometry, proteomics).