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solublempnn

Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation. Reach for this skill when designs from vanilla ProteinMPNN are aggregating or going to inclusion bodies, when redesigning a membrane-adjacent fold for soluble expression, or when an E. coli expression screen is the next step.

78

Quality

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SecuritybySnyk

Low

Low-risk findings worth noting

SKILL.md
Quality
Evals
Security

Low

Low-risk findings.

2 low severity findings. Worth noting, but not necessarily harmful.

Low

W011: Third-party content exposure detected (indirect prompt injection risk).

What this means

The skill exposes the agent to untrusted, user-generated content from public third-party sources, creating a risk of indirect prompt injection. This includes browsing arbitrary URLs, reading social media posts or forum comments, and analyzing content from unknown websites.

Why it was flagged

The required workflow clones and runs the `ProteinMPNN` repo and then uses the runner’s parsing of the input `--pdb_path` (and chains/JSONL keyed by PDB stem); any externally provided PDB text is outsider-authored free text that can be ingested/parsed into the model context at runtime.

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Low

W012: Unverifiable external dependency detected (runtime URL that controls agent).

What this means

The skill fetches instructions or code from an external URL at runtime, and the fetched content directly controls the agent’s prompts or executes code. This dynamic dependency allows the external source to modify the agent’s behavior without any changes to the skill itself.

Why it was flagged

The skill runs a runtime "git clone --depth 1 https://github.com/dauparas/ProteinMPNN.git" and then executes the repo's python script, meaning it fetches and executes remote code from https://github.com/dauparas/ProteinMPNN.git which is required for the job.

Repository
UnicomAI/wanwu
Audited
Security analysis
Snyk

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