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Generate a therapeutic indication dossier. Covers the patient population, epidemiology, disease biology, standard of care, regulatory precedent, and landmark clinical trials.

A set of resources to help me write all kinds of internal communications, using the formats that my company likes to use. Claude should use this skill whenever asked to write some sort of internal communications (status reports, leadership updates, 3P updates, company newsletters, FAQs, incident reports, project updates, etc.).

本地知识库集成 - 文档检索、投喂、双轨模式切换

Use this skill when the user wants intellectual understanding — learning how or why something works, not getting a task done or soliciting Claude's judgment. Trigger for: - Explicit learning requests: teach, explain, ELI5, walk me through, quiz me, flashcards, "I'm rusty on"; definitions ("what is X") - Terse concept names implying "help me understand this": "Galois theory," "transformers, from scratch" - Confusion signals: "won't stick," "keep mixing these up," "not getting it" - Learning-path questions: prerequisites, sequencing, what to study before X - Conceptual questions about mechanisms, causes, or dynamics Don't trigger for: - Tasks: coding, writing, calculation, translation, factual lookup, news updates - Personal troubleshooting; resource/textbook recommendations - Claude's evaluative verdict: opinion prompts ("do you think X", "settle this", "honest take", "is X dead / still taken seriously") and interpretive takes ("was X really as harsh as people say")

Inverse-fold a backbone with ligand, nucleic-acid, and metal context using LigandMPNN (Dauparas et al. 2023, github.com/dauparas/LigandMPNN). Reach for this skill to redesign the residues lining a binding pocket around a bound small molecule or cofactor, to design metal-coordinating sites where the geometry must be respected, or to get threaded designed-sequence PDBs out of any MPNN run.

Find, verify, and synthesize scientific literature — from "what's the seminal paper for X" through full multi-source reviews. Covers grounding claims in real retrieved sources, avoiding fabricated citations, handling retractions, and calibrating confidence to evidence strength.

Register a model service in the managed family — a local model server container the daemon starts/stops on demand, or a remote upstream model API (https). Read the runbook, allocate a port (local only), compose idempotent start/stop scripts (local only), register once. Load when the user wants a model service available for inference, or when list_compute shows managed endpoints.

将 MCP Server 的工具列表转换为 Skill 格式的结构化 Markdown 文档

Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).

Professional DOCX document creation, editing, and formatting using OpenXML SDK (.NET). Three pipelines: (A) create new documents from scratch, (B) fill/edit content in existing documents, (C) apply template formatting with XSD validation gate-check. MUST use this skill whenever the user wants to produce, modify, or format a Word document — including when they say "write a report", "draft a proposal", "make a contract", "fill in this form", "reformat to match this template", or any task whose final output is a .docx file. Even if the user doesn't mention "docx" explicitly, if the task implies a printable/formal document, use this skill.

Typed knowledge graph for structured agent memory and composable skills. Use when creating/querying entities (Person, Project, Task, Event, Document), linking related objects, enforcing constraints, planning multi-step actions as graph transformations, or when skills need to share state. Trigger on "remember", "what do I know about", "link X to Y", "show dependencies", entity CRUD, or cross-skill data access.

操作 知识网络（BKN）— 构建知识网络、查询 Schema/实例、语义搜索、执行 Action。 操作指标（Metric）— 指标定义的 CRUD、搜索、校验、查询数据、试运行。 操作数据源与数据视图 — 数据源连接与查询、原子/自定义视图浏览与 SQL 查询。 操作 Vega 可观测平台 — 查询 Catalog/资源/连接器类型、健康巡检。 当用户提到"知识网络"、"知识图谱"、"查询对象类"、"执行 Action"、 "指标管理"、"创建指标"、"查询指标"、"试运行指标"、"校验指标"、 "数据源"、"数据视图"、"原子视图"、"Catalog"、"Vega"、 "健康检查"、"巡检"等意图时自动使用。

当用户输入以 "fy " 开头的翻译请求时使用此 skill。支持中英互译，如果是其他语种则翻译成中文。触发条件：输入 "fy" 后面跟要翻译的内容，例如 "fy test" 返回 "测试"。

Structure prediction using OpenFold3, an open-weights PyTorch reproduction of AlphaFold3 from the AlQuraishi Lab. Use this skill when predicting protein/nucleic-acid/ligand complex structures with an Apache-2.0-licensed AF3 reimplementation.

Judge and reshape the STORY a paper's figures tell. Input is the work itself — manuscript (or abstract) + figure deck — no hand-written brief. `paper_brief_prompt(abstract, captions)` hands you the prompt to write the brief yourself (pitch/vision/per-figure-claims); then you play a handling editor over the full deck and return hook_verdict (would Fig 1 make me send this for review?), arc (hook→mechanism→evidence→application), figure_moves (panels in the wrong figure), missing_panels (concrete analyses to RUN), kill_list, and boldest_defensible_fig1. Hands per-figure claims to `figure-composer`. Load when writing or revising a paper.

Use this skill whenever the user wants to do anything with PDF files. This includes reading or extracting text/tables from PDFs, combining or merging multiple PDFs into one, splitting PDFs apart, rotating pages, adding watermarks, creating new PDFs, filling PDF forms, encrypting/decrypting PDFs, extracting images, and OCR on scanned PDFs to make them searchable. If the user mentions a .pdf file or asks to produce one, use this skill.

Comprehensive PDF manipulation toolkit for extracting text and tables, creating new PDFs, merging/splitting documents, and handling forms. When Claude needs to fill in a PDF form or programmatically process, generate, or analyze PDF documents at scale.

Use this skill when the user has attached a PDF, paper, report, or other document and the answer needs content from more than one place in it: summarize the methods or any other section, compare sections, find where a topic is discussed, read a value or label off a figure or chart, or find/list/extract every instance of something across the whole document (datasets, benchmarks, citations, figures, table rows, accession numbers — including appendices). Parses the PDF once with a deterministic Python kernel: `pdf_pages` (pages as persistent text, or high-res images), `pdf_outline` (embedded TOC), `pdf_scan` (a lexical pre-filter that narrows a long doc to candidate pages), `pdf_grep` (regex sweep for exhaustive pattern extraction). You read the shortlist and do the relevance / summary / extraction judgment yourself. For PDF creation/manipulation, use reportlab/pypdf directly.

Use this skill whenever the user wants to do anything with PDF files. This includes reading or extracting text/tables from PDFs, combining or merging multiple PDFs into one, splitting PDFs apart, rotating pages, adding watermarks, creating new PDFs, filling PDF forms, encrypting/decrypting PDFs, extracting images, and OCR on scanned PDFs to make them searchable. If the user mentions a .pdf file or asks to produce one, use this skill.

官方Microsoft Playwright CLI网页自动化工具，支持所有主流浏览器的无头/有头自动化操作，包括页面导航、元素交互、截图、录制、测试等功能。当用户提到网页自动化、浏览器操作、爬虫、截图、录制用户操作、E2E测试时触发。