sequence-alignment

Trigger when user needs to align DNA/protein sequences, compare biological sequences, search for similar sequences in databases, or perform BLAST-based similarity analysis. Use for bioinformatics sequence comparison tasks.

Install with Tessl CLI

npx tessl i github:aipoch/medical-research-skills --skill sequence-alignment

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Review — 81%

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Learn more

Validation — 10 / 11 Passed

Validation for skill structure

SKILL.md

Review

Evals

Evaluation results

100%

25%

Unknown Bacterial Gene Identification

Correct BLAST program and database selection for nucleotide search

Criteria

Without context

With context

Uses scripts/main.py

100%

Correct program: blastn

100%

Correct database: nt

100%

Stringent e-value

100%

Max hits limited to 5

100%

Output saved to file

100%

Text output format

100%

Results file exists

100%

Run log documents command

100%

Without context: $0.3794 · 2m 34s · 19 turns · 25 in / 6,901 out tokens

With context: $0.9090 · 3s · 1 turns · 3 in / 71 out tokens

98%

35%

Enzyme Homolog Discovery for Drug Target Research

Protein sequence alignment with appropriate program, database, and output format

Criteria

Without context

With context

Uses scripts/main.py

83%

Correct program: blastp

100%

Curated protein database

100%

Stringent e-value

100%

JSON output format

100%

Output saved to file

50%

100%

JSON file is valid

100%

Notes document rationale

100%

No extra packages used

100%

Without context: $0.5343 · 3m 50s · 30 turns · 32 in / 8,443 out tokens

With context: $0.6325 · 2m 32s · 24 turns · 29 in / 5,053 out tokens

100%

20%

Pathogen ORF Functional Annotation

Cross-type BLAST program selection and CSV output for translated nucleotide search

Criteria

Without context

With context

Uses scripts/main.py

100%

Correct program: blastx

100%

Protein database used

100%

Max hits set to 20

87%

100%

Stringent e-value

100%

CSV output format

66%

100%

Output saved to file

87%

100%

CSV file is valid

77%

100%

Methods doc explains program choice

100%

Without context: $0.6702 · 18m 8s · 32 turns · 37 in / 8,523 out tokens

With context: $0.4142 · 3m 38s · 18 turns · 23 in / 4,564 out tokens

Evaluated: 1 day ago
Agent: Claude Code

Table of Contents

Unknown Bacterial Gene Identification Enzyme Homolog Discovery for Drug Target Research Pathogen ORF Functional Annotation

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