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tooluniverse-peptide-target-deorphanization

Find the real protein target(s) of a peptide from its sequence — peptide target deorphanization / off-target identification, for ANY target class (GPCR, ion channel, protease, cytokine/growth-factor receptor, enzyme, integrin), not only GPCRs. Use when a peptide has a phenotype but does not bind its hypothesized target, when a peptide binds a target in one species or assay but not another, or to screen candidate targets for an orphan peptide. A target-class router steers a multi-route keyless pipeline (PROSITE/ELM motif, BLAST homology, HGNC/InterPro/GPCRdb/GtoPdb target-family enumeration, OpenTargets phenotype anchor, EnsemblCompara/Alliance cross-species reconciliation) plus optional NVIDIA-NIM co-folding (Boltz2, AlphaFold2-Multimer, OpenFold3) for structural confirmation.

72

Quality

88%

Does it follow best practices?

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SecuritybySnyk

Low

Low-risk findings worth noting

SKILL.md
Quality
Evals
Security

Quality

Content

77%

Reviews the quality of instructions and guidance provided to agents. Good implementation is clear, handles edge cases, and produces reliable results.

A highly actionable, well-sequenced skill body with strong workflow checkpoints and progressive disclosure to a real references file. It loses points on conciseness (verbosity and repetition) and on a single broken reference to a missing evals/ directory.

Suggestions

Trim repeated emphases and parenthetical asides (e.g. the "name-level guess" caution and GLP-1/DPP4 detail appear multiple times); move worked-detail that already lives in references/phases.md out of SKILL.md.

Either add the evals/ directory with evals.json or remove/soften the reference to it so all navigation paths resolve.

Consolidate the target-class list (GPCR, ion channel, protease, cytokine/growth-factor receptor, enzyme, integrin) into one place rather than restating the classification across several sections.

DimensionReasoningScore

Conciseness

Dense and largely assumes Claude's intelligence, but it is verbose: heavy parentheticals, repeated emphases, and the GLP-1/name-level-guess caution restated several times, with detail that the references file already covers.

2 / 3

Actionability

Fully executable, copy-paste-ready bash commands for both scripts with every flag explained, plus a validated control invocation with the exact sequence and expected output.

3 / 3

Workflow Clarity

A clear six-phase sequence with a phase→tools table, explicit Phase-0 tool verification with fallback substitution, and a co-fold dry-run feedback loop before committing GPU spend.

3 / 3

Progressive Disclosure

SKILL.md is a clean overview pointing one level deep to references/phases.md and the scripts, but the body references evals/evals.json which is not present in the bundle, a navigation path that does not resolve.

2 / 3

Total

10

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12

Passed

Description

100%

Based on the skill's description, can an agent find and select it at the right time? Clear, specific descriptions lead to better discovery.

A strong, third-person description that concretely states capabilities, gives explicit use-when triggers in natural language, and carves out a distinctive niche. No verbosity or first/second-person voice issues.

DimensionReasoningScore

Specificity

Lists multiple concrete actions — "Find the real protein target(s)", "off-target identification", "screen candidate targets", target-class routing, and optional co-folding for structural confirmation.

3 / 3

Completeness

Explicitly answers both what (find real protein targets of a peptide) and when via a "Use when..." clause enumerating three triggering scenarios.

3 / 3

Trigger Term Quality

Strong coverage of natural user phrasing: "peptide target deorphanization / off-target identification", "does not bind its hypothesized target", "binds a target in one species or assay but not another", "orphan peptide".

3 / 3

Distinctiveness Conflict Risk

Highly specific niche (peptide deorphanization across named target classes) with distinct triggers; very unlikely to fire for an unrelated skill.

3 / 3

Total

12

/

12

Passed

Validation

100%

Checks the skill against the spec for correct structure and formatting. All validation checks must pass before discovery and implementation can be scored.

Validation16 / 16 Passed

Validation for skill structure

No warnings or errors.

Repository
mims-harvard/ToolUniverse
Reviewed

Table of Contents

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