Set an explicit objective, success criteria, and stopping conditions for the current OpenScience session.

Foundation model for image segmentation with zero-shot transfer. Use when you need to segment any object in images using points, boxes, or masks as prompts, or automatically generate all object masks in an image.

Guarantee valid JSON/XML/code structure during generation, use Pydantic models for type-safe outputs, support local models (Transformers, vLLM), and maximize inference speed with Outlines - dottxt.ai's structured generation library

Meta's 7-8B specialized moderation model for LLM input/output filtering. 6 safety categories - violence/hate, sexual content, weapons, substances, self-harm, criminal planning. 94-95% accuracy. Deploy with vLLM, HuggingFace, Sagemaker. Integrates with NeMo Guardrails.

Fast tokenizers optimized for research and production. Rust-based implementation tokenizes 1GB in <20 seconds. Supports BPE, WordPiece, and Unigram algorithms. Train custom vocabularies, track alignments, handle padding/truncation. Integrates seamlessly with transformers. Use when you need high-performance tokenization or custom tokenizer training.

OpenAI's model connecting vision and language. Enables zero-shot image classification, image-text matching, and cross-modal retrieval. Trained on 400M image-text pairs. Use for image search, content moderation, or vision-language tasks without fine-tuning. Best for general-purpose image understanding.

Vision-language pre-training framework bridging frozen image encoders and LLMs. Use when you need image captioning, visual question answering, image-text retrieval, or multimodal chat with state-of-the-art zero-shot performance.

Autonomous AI agent platform for building and deploying continuous agents. Use when creating visual workflow agents, deploying persistent autonomous agents, or building complex multi-step AI automation systems.

Query STRING API for protein-protein interactions (59M proteins, 20B interactions). Network analysis, GO/KEGG enrichment, interaction discovery, 5000+ species, for systems biology.

Query Reactome REST API for pathway analysis, enrichment, gene-pathway mapping, disease pathways, molecular interactions, expression analysis, for systems biology studies.

Query PubChem via PUG-REST API/PubChemPy (110M+ compounds). Search by name/CID/SMILES, retrieve properties, similarity/substructure searches, bioactivity, for cheminformatics.

Direct REST API access to KEGG (academic use only). Pathway analysis, gene-pathway mapping, metabolic pathways, drug interactions, ID conversion. For Python workflows with multiple databases, prefer bioservices. Use this for direct HTTP/REST work or KEGG-specific control.

Query and download public cancer imaging data from NCI Imaging Data Commons using idc-index. Use for accessing large-scale radiology (CT, MR, PET) and pathology datasets for AI training or research. No authentication required. Query by metadata, visualize in browser, check licenses.

Query openFDA API for drugs, devices, adverse events, recalls, regulatory submissions (510k, PMA), substance identification (UNII), for FDA regulatory data analysis and safety research.

Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic research.

Access and analyze comprehensive drug information from the DrugBank database including drug properties, interactions, targets, pathways, chemical structures, and pharmacology data. This skill should be used when working with pharmaceutical data, drug discovery research, pharmacology studies, drug-drug interaction analysis, target identification, chemical similarity searches, ADMET predictions, or any task requiring detailed drug and drug target information from DrugBank.

Work with Data Commons, a platform providing programmatic access to public statistical data from global sources. Use this skill when working with demographic data, economic indicators, health statistics, environmental data, or any public datasets available through Data Commons. Applicable for querying population statistics, GDP figures, unemployment rates, disease prevalence, geographic entity resolution, and exploring relationships between statistical entities.

LockStore, InMemoryLockStore, LocksCapability and withLocks for multi-instance coordination in TanStack AI. Ships in @tanstack/ai — NOT in @tanstack/ai-persistence. Separate from AIPersistence state stores — not a stores key, not composable. InMemoryLockStore vs a distributed (e.g. Cloudflare Durable Object) lock, lease recovery, AbortSignal in critical sections. Use when sandbox or other middleware needs cross-worker mutual exclusion — NOT for storing messages/runs (use withPersistence).

Server chat state with withPersistence from @tanstack/ai-persistence. Authoritative transcript, run lifecycle, durable interrupts/approvals, chatParamsFromRequest, reconstructChat, snapshotStreaming. Use when the server owns history, multi-device, or durable tool approvals. NOT client localStorage (see ai-core/client-persistence in @tanstack/ai) and NOT stream reconnect alone.

Durability and state persistence for TanStack AI chats with @tanstack/ai-persistence. Routes to server chat persistence (withPersistence), client persistence (localStorage/IndexedDB), the store contracts, and adapter recipes. Distinguishes delivery durability (resumable streams) from conversation state. Use when conversations must survive reloads, multi-device, approvals, or server restarts — NOT for stream reconnect alone.