Query Reactome REST API for pathway analysis, enrichment, gene-pathway mapping, disease pathways, molecular interactions, expression analysis, for systems biology studies.

Query PubChem via PUG-REST API/PubChemPy (110M+ compounds). Search by name/CID/SMILES, retrieve properties, similarity/substructure searches, bioactivity, for cheminformatics.

Direct REST API access to KEGG (academic use only). Pathway analysis, gene-pathway mapping, metabolic pathways, drug interactions, ID conversion. For Python workflows with multiple databases, prefer bioservices. Use this for direct HTTP/REST work or KEGG-specific control.

Query and download public cancer imaging data from NCI Imaging Data Commons using idc-index. Use for accessing large-scale radiology (CT, MR, PET) and pathology datasets for AI training or research. No authentication required. Query by metadata, visualize in browser, check licenses.

Query openFDA API for drugs, devices, adverse events, recalls, regulatory submissions (510k, PMA), substance identification (UNII), for FDA regulatory data analysis and safety research.

Query Ensembl genome database REST API for 250+ species. Gene lookups, sequence retrieval, variant analysis, comparative genomics, orthologs, VEP predictions, for genomic research.

Access and analyze comprehensive drug information from the DrugBank database including drug properties, interactions, targets, pathways, chemical structures, and pharmacology data. This skill should be used when working with pharmaceutical data, drug discovery research, pharmacology studies, drug-drug interaction analysis, target identification, chemical similarity searches, ADMET predictions, or any task requiring detailed drug and drug target information from DrugBank.

Work with Data Commons, a platform providing programmatic access to public statistical data from global sources. Use this skill when working with demographic data, economic indicators, health statistics, environmental data, or any public datasets available through Data Commons. Applicable for querying population statistics, GDP figures, unemployment rates, disease prevalence, geographic entity resolution, and exploring relationships between statistical entities.

Access ClinPGx pharmacogenomics data (successor to PharmGKB). Query gene-drug interactions, CPIC guidelines, allele functions, for precision medicine and genotype-guided dosing decisions.

Generate concise (3-4 page), focused medical treatment plans in LaTeX/PDF format for all clinical specialties. Supports general medical treatment, rehabilitation therapy, mental health care, chronic disease management, perioperative care, and pain management. Includes SMART goal frameworks, evidence-based interventions with minimal text citations, regulatory compliance (HIPAA), and professional formatting. Prioritizes brevity and clinical actionability.

Write comprehensive clinical reports including case reports (CARE guidelines), diagnostic reports (radiology/pathology/lab), clinical trial reports (ICH-E3, SAE, CSR), and patient documentation (SOAP, H&P, discharge summaries). Full support with templates, regulatory compliance (HIPAA, FDA, ICH-GCP), and validation tools.

Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based guidelines with decision algorithms). Supports GRADE evidence grading, statistical analysis (hazard ratios, survival curves, waterfall plots), biomarker integration, and regulatory compliance. Outputs publication-ready LaTeX/PDF format optimized for drug development, clinical research, and evidence synthesis.

Identify and repair degradation in system prompt, external memory, and skills preventing you from following instructions or remembering information as well as you should.

LockStore, InMemoryLockStore, LocksCapability and withLocks for multi-instance coordination in TanStack AI. Ships in @tanstack/ai — NOT in @tanstack/ai-persistence. Separate from AIPersistence state stores — not a stores key, not composable. InMemoryLockStore vs a distributed (e.g. Cloudflare Durable Object) lock, lease recovery, AbortSignal in critical sections. Use when sandbox or other middleware needs cross-worker mutual exclusion — NOT for storing messages/runs (use withPersistence).

Pluggable, category-toggleable debug logging for TanStack AI activities. Toggle with `debug: true | false | DebugConfig` on chat(), summarize(), generateImage(), generateSpeech(), generateTranscription(), generateVideo(). Categories: request, provider, output, middleware, tools, agentLoop, config, errors. Pipe into pino/winston/etc via `debug: { logger }`. Errors log by default even when `debug` is omitted; silence with `debug: false`.

Connect useChat to a non-TanStack-AI backend through custom connection adapters. ConnectConnectionAdapter (single async iterable) vs SubscribeConnectionAdapter (separate subscribe/send). Customize fetchServerSentEvents() and fetchHttpStream() with auth headers, custom URLs, and request options. Import from framework package, not @tanstack/ai-client.

Browser chat persistence on useChat / ChatClient: localStoragePersistence, sessionStoragePersistence, indexedDBPersistence. Client-authoritative (adapter, full transcript) vs server-authoritative (persistence: true, no client cache). Reload restore, pending interrupts, mid-stream rejoin with delivery durability. Use for SPA reload durability — NOT server history alone. Also covers generation hooks (useGenerateImage etc.), which take only the server-driven mode: persistence: true hydrates the last generation for the (REQUIRED) threadId from the server on mount and repaints status/result/error, nothing is cached in the browser. No extra package: the adapters ship in the framework packages.

End-to-end chat implementation: server endpoint with chat() and toServerSentEventsResponse(), client-side useChat hook with fetchServerSentEvents(), message rendering with UIMessage parts, multimodal content, thinking/reasoning display. Covers streaming states, connection adapters, and message format conversions. NOT Vercel AI SDK — uses chat() not streamText().

Server-side AG-UI streaming protocol implementation: StreamChunk event types (RUN_STARTED, TEXT_MESSAGE_START/CONTENT/END, TOOL_CALL_START/ARGS/END, RUN_FINISHED, RUN_ERROR, STEP_STARTED/STEP_FINISHED, STATE_SNAPSHOT/DELTA, CUSTOM), toServerSentEventsStream() for SSE format, toHttpStream() for NDJSON format. For backends serving AG-UI events without client packages.

Provider adapter selection and configuration: openaiText, anthropicText, geminiText, ollamaText, grokText, groqText, openRouterText, bedrockText, byteplusText, openaiCompatible. Per-model type safety with modelOptions, reasoning/thinking configuration, runtime adapter switching, extendAdapter() for custom models, createModel(). Generic OpenAI-compatible providers (DeepSeek, Together, Fireworks, etc.) via openaiCompatible({ baseURL, apiKey, models }) from @tanstack/ai-openai/compatible. API key env vars: OPENAI_API_KEY, ANTHROPIC_API_KEY, GOOGLE_API_KEY/GEMINI_API_KEY, XAI_API_KEY, GROQ_API_KEY, OPENROUTER_API_KEY, OLLAMA_HOST, BEDROCK_API_KEY (or AWS_BEARER_TOKEN_BEDROCK). BytePlus needs TWO keys: ARK_API_KEY (ModelArk — chat/video/image) and BYTEPLUS_VOICE_API_KEY (Seed Speech — TTS/transcription); neither is a fallback for the other.