Generate ~5 actionable research topic recommendations by querying PubMed E-utilities; use when a user provides a research direction/constraints and needs evidence-backed topic ideas quickly.

Build complex Boolean query strings for precise PubMed/MEDLINE literature retrieval. Trigger when user needs MeSH term mapping, Boolean query construction, advanced PubMed filters, citation searching, systematic review search strategy, or clinical query optimization.

Direct REST API access to PubMed. Advanced Boolean/MeSH queries, E-utilities API, batch processing, citation management. For Python workflows, prefer biopython (Bio.Entrez). Use this for direct HTTP/REST work or custom API implementations.

Use when building or maintaining a persistent personal knowledge base (second brain) in Obsidian where an LLM incrementally ingests sources, updates entity/concept pages, maintains cross-references, and keeps a synthesis current. Triggers include "second brain", "Obsidian wiki", "personal knowledge management", "ingest this paper/article/book", "build a research wiki", "compound knowledge", "Memex", or whenever the user wants knowledge to accumulate across sessions instead of being re-derived by RAG on every query.

Programmatic access to the PubChem database (via PUG-REST API and PubChemPy) for searching chemical compounds, retrieving physicochemical properties, performing structure similarity/substructure searches, and obtaining bioactivity data.

Use proactively whenever LLM API costs come up -- or should. Triggers include: 'my AI costs are too high', 'optimize token usage', 'which model should I use', 'LLM spend is out of control', 'implement prompt caching', 'we're about to launch an AI feature', 'build me an AI endpoint'. Don't wait for an explicit cost complaint -- if someone is building an AI feature, designing an LLM endpoint, or choosing between models, cost architecture belongs in the conversation. Apply immediately when any of these are true: a system prompt appears that exceeds a few hundred tokens, all requests are hitting the same model, max_tokens is not set, or no per-feature cost logging exists. NOT for RAG pipeline design (use rag-architect). NOT for improving prompt quality or effectiveness (use senior-prompt-engineer).

Download PubMed/PMC literature using officially permitted PMC methods. Whenever the user wants to download PMC full text, batch-retrieve PMC Open Access Subset articles, save full text corresponding to PMID/PMCID locally, or needs to determine whether a PubMed article can be l...

Use when building a Kubernetes Operator — custom controllers that reconcile CRD state. Triggers on "build an operator", "CRD design", "reconcile loop", "controller-runtime", "kubebuilder", "operator-sdk", "metacontroller", "KOPF", "operator capability levels", or "custom resource". Ships CRD validator, reconcile-loop linter, and OperatorHub capability auditor (all stdlib Python), 4 references on the operator pattern + CRD design + reconcile patterns + tooling landscape, and a /operator-audit slash command. NOT a generic k8s skill — specifically the Operator pattern.

Expert system for generating comprehensive biomedical phenotype introductions with structured academic content. Use when users request detailed explanations of cellular phenotypes including concept, mechanism, regulation, and detection methods in Chinese academic writing.

Use when writing, reviewing, or committing code to enforce Karpathy's 4 coding principles — surface assumptions before coding, keep it simple, make surgical changes, define verifiable goals. Triggers on "review my diff", "check complexity", "am I overcomplicating this", "karpathy check", "before I commit", or any code quality concern where the LLM might be overcoding.

Extract experimental materials and instrument information from PDFs (or PDF-derived text/Markdown) into three CSV tables; use when a paper/report contains sections like Materials and Methods, Key Resources Table, Reagents, Antibodies, Consumables, Software, Equipment, Instruments, or Reagent Preparation.

Access the RCSB Protein Data Bank (PDB) to search, download, and programmatically retrieve 3D macromolecular structures and metadata; use when you need structure discovery (text/sequence/3D similarity) or automated structural data ingestion for structural biology and drug discovery workflows.

Generates comprehensive academic introductions for biological pathways, including signaling processes, markers, and inhibitors. Use when the user asks to introduce a pathway, molecule, or gene.

Runs the human-verification lane of an agent loop, and proves review happened before work is called done. Builds a single-file HTML review page, collects batched feedback as a structured artifact instead of chat prose, and runs a gate that refuses to close while a BLOCKER is open, the reviewer is unnamed, or nobody has reviewed at all. Use when a plan, spec, RFC, report, landing page, migration, or any irreversible action needs human sign-off before shipping, or on requests such as 'get sign-off', 'have someone check this', 'hold until reviewed', 'needs approval first'. NOT for making AI text sound human (use content-humanizer or behuman). NOT for reviewing code diffs (use md-review or code-reviewer).

Use when analyzing biotech patent landscapes, identifying white spaces in pharmaceutical IP, tracking competitor patents, or assessing freedom to operate for drug development. Provides comprehensive patent analysis and strategic insights for life sciences innovation.

Use when mapping patent claims to products, analyzing patent infringement, or preparing freedom-to-operate analyses. Compares patent claims against product features for biotech and pharmaceutical IP assessment.

Orchestrate free opencode workers from Claude Code to cut token costs. Use when delegating grunt work to a single worker or a parallel swarm (scout/coder/tester) with worktree isolation, benchmarking against opencode, or when the user says "spawn a worker", "swarm", "delegate to opencode", or "/oc".

Search 10 academic paper databases via REST APIs for research papers, preprints, and scholarly articles. Covers PubMed, PMC (full text), bioRxiv, medRxiv, arXiv, OpenAlex, Crossref, Semantic Scholar, CORE, Unpaywall. Use when searching for papers, citations, DOI/PMID lookups, abstracts, full text, open access, preprints, citation graphs, author search, or any scholarly literature query. Triggers on mentions of any supported database or requests like "find papers on X" or "look up this DOI".

Helm chart development agent skill and plugin for Claude Code, Codex, Gemini CLI, Cursor, OpenClaw — chart scaffolding, values design, template patterns, dependency management, security hardening, and chart testing. Use when: user wants to create or improve Helm charts, design values.yaml files, implement template helpers, audit chart security (RBAC, network policies, pod security), manage subcharts, or run helm lint/test.

Access the OpenAlex database (240M+ scholarly works) for bibliometric analysis, literature search, and citation tracking; use when you need to query works/authors/institutions/concepts without an API key.