Answer biomedical FACTUAL / recall / multiple-choice questions by querying ToolUniverse database tools instead of answering from memory. Triggers on any 'which gene/drug/variant/disease/pathway/miRNA/TF...' lookup, any question phrased 'according to <database>' (DisGeNet, OMIM, MSigDB, miRDB, GTRD, MGI, Ensembl, ClinVar, ChEMBL, OpenTargets, Reactome, GtoPdb, UniProt...), and multiple-choice biology/medicine knowledge questions where one option must be verified against an authoritative source. NOT for analyzing user-supplied data files (CSV/VCF/h5ad → use the data-analysis router) and NOT for open-ended literature synthesis. Use whenever a single correct answer exists in a public biomedical database and could be looked up rather than guessed.

Comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiling for drug candidates. Integrates ADMET-AI predictions, SwissADME drug-likeness, PubChemTox experimental toxicity, ChEMBL clinical data, Lipinski rule-of-five, and CYP interaction data. Use for drug-likeness assessment, BBB penetration, bioavailability, hepatotoxicity prediction, ADME/PK profiling, or screening compound libraries before lab testing.

Clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Use for VUS classification, pathogenicity assessment with cited criteria, structure-based variant impact (AlphaFold/PDB), non-coding/regulatory variant effect prediction with sequence deep-learning models (AlphaGenome, Enformer, Borzoi, ChromBPNet, Evo 2), and producing clinical-grade variant reports for return of results or molecular tumor boards. Use this whenever a user asks about a variant's significance, an intronic/promoter/enhancer/UTR non-coding variant's functional impact, or needs ACMG classification — even if they don't say "ACMG".

Gene-disease association analysis across DisGeNET, OpenTargets, Monarch, OMIM, GenCC, Orphanet, Gene2Phenotype (G2P). Cross-references multiple sources for evidence-graded association reports with concordance scoring (5/5 sources agree → strong, 1/5 → weak). Use for 'which diseases is gene X associated with' or 'which genes cause disease Y' queries with quantitative confidence, including clinical-panel-based curation (developmental disorders, cancer, cardiac, skeletal, eye, skin panels).

Retrieve gene expression and omics datasets from ArrayExpress and BioStudies with gene disambiguation and quality assessment. Use for finding RNA-seq/microarray datasets by organism/tissue/condition, comparing across studies (case-control, time-series, dose-response), and assessing dataset suitability before downloading. Always uses English search terms.

Drug regulatory and approval research — FDA substance registry, ATC/EPC classification, EMA decisions, generic-drug status, FDA Orange Book exclusivity, NDA/BLA pathways. Use for jurisdiction-aware approval status (FDA vs EMA), generic vs brand availability, exclusivity expiry tracking, and regulatory pathway selection. Always specifies the market when reporting status.

Retrieve chemical compound data from PubChem and ChEMBL with disambiguation, cross-referencing, and stereochemistry handling. Use for resolving compound names to SMILES/InChI/CID/ChEMBL IDs (including OPSIN deterministic IUPAC-name-to-structure parsing), fetching molecular properties, distinguishing isomers/stereo forms, and cross-validating identity across databases. Always use English compound names; flags ambiguous queries (e.g., Vitamin D has multiple forms).

Answer biomedical FACTUAL / recall / multiple-choice questions by querying ToolUniverse database tools instead of answering from memory. Triggers on any 'which gene/drug/variant/disease/pathway/miRNA/TF...' lookup, any question phrased 'according to <database>' (DisGeNet, OMIM, MSigDB, miRDB, GTRD, MGI, Ensembl, ClinVar, ChEMBL, OpenTargets, Reactome, GtoPdb, UniProt...), and multiple-choice biology/medicine knowledge questions where one option must be verified against an authoritative source. NOT for analyzing user-supplied data files (CSV/VCF/h5ad → use the data-analysis router) and NOT for open-ended literature synthesis. Use whenever a single correct answer exists in a public biomedical database and could be looked up rather than guessed.

Use when defining or editing MPS intentions (the Alt+Enter context-action aspect) — adding `IntentionDeclaration` roots, parameterized or surround-with variants, description/isApplicable/execute blocks, child-filter functions, factory-initialized AST splicing, or debugging why an intention is not offered. Lives in the language's `intentions` model and uses `jetbrains.mps.lang.intentions`.

Build lean, opinionated products using the 37signals philosophy from "Getting Real", "Rework", and "Shape Up". Use when the user mentions "Getting Real", "Rework", "Shape Up", "37signals", "Basecamp method", "six-week cycles", "fixed time variable scope", "appetite vs estimates", "betting table", "breadboarding", "fat marker sketch", "build less", "underdo the competition", "opinionated software", "we have too many meetings", "how do we ship faster", or "stop overbuilding". Also trigger when cutting scope to ship sooner, running a small team, or avoiding long-term roadmaps. Covers shaping, betting, building, and the art of saying no. For MVP validation, see lean-startup. For design sprints, see design-sprint.

Interface design principles for package APIs — where configuration, behavior, and state belong across schema, endpoint, and hook layers. Use when adding or changing options, behavior, or state in packages/*.

Implements and validates existing PRP plans and corrects reviewed or failing-CI pull requests. Always use when executing an implementation plan, implementing an issue that already has a local or published plan, correcting a PR from a PRP review report or CI failure, when another PRP workflow reaches its implementation or correction step, or when the user invokes /prp-implement.

Implements and validates existing PRP plans and corrects reviewed or failing-CI pull requests. Always use when executing an implementation plan, implementing an issue that already has a local or published plan, correcting a PR from a PRP review report or CI failure, when another PRP workflow reaches its implementation or correction step, or when the user invokes /prp-implement.

Polish and refine existing motion against the transitions.dev motion-token scale — duration, distance, scale, blur, and easing — plus the rules for WHEN each token applies (open/close asymmetry, hover-in vs hover-out, stagger offsets, and intent delays). An add-on to the transitions-dev skill, focused on tuning what already animates rather than adding new transitions. Use when the user asks to "polish my transitions", "refine the motion", "tune the timing / easing", "make the animation feel better / less janky", "tighten the durations", "fix the stagger", "align to the motion tokens", "audit the motion", "review my animations", "scan for ad-hoc transitions", "tokenize my animations", or runs the commands transitions review or transitions polish. Also drives the Refine panel's Small refinement feature. Triggers on "motion polish", "transition polish", "refine motion", "timing feels off", "too slow / too fast", "stagger", "delay", "open close timing", "hover in out".

Create and edit JSON Canvas files (.canvas) with nodes, edges, groups, and connections. Use when working with .canvas files, creating visual canvases, mind maps, flowcharts, or when the user mentions Canvas files in Obsidian.

Find bugs, security vulnerabilities, and code quality issues in local branch changes. Use when asked to review changes, find bugs, security review, or audit code on the current branch.

Alias for sentry-skills:pr-writer. Use when users explicitly ask for "create-pr" or reference the legacy skill name. Redirects to the canonical PR writing workflow.

Create a git branch following Sentry naming conventions. Use when asked to "create a branch", "new branch", "start a branch", "make a branch", "switch to a new branch", or when starting new work on the default branch.

Create and edit JSON Canvas files (.canvas) with nodes, edges, groups, and connections. Use when working with .canvas files, creating visual canvases, mind maps, flowcharts, or when the user mentions Canvas files in Obsidian.

Create and edit JSON Canvas files (.canvas) with nodes, edges, groups, and connections. Use when working with .canvas files, creating visual canvases, mind maps, flowcharts, or when the user mentions Canvas files in Obsidian.