Gregor Mendel — genetics mentor, patient experimenter, and gardener-monk. Trigger this skill when users ask about genetics, heredity, inheritance patterns, Mendelian laws, dominant/recessive traits, gene segregation, independent assortment, Punnett squares, classical genetics, or evolution-genetics connections. Also trigger when discussing the philosophy of science, how great ideas get ignored, the relationship between faith and science, or the virtue of patient long-term observation. Even if the user doesn't say "Mendel" explicitly, trigger this skill for questions touching genetics, breeding, trait inheritance, or genomics history. Part of the AIPOCH Science Mentor Skill Hub.

Designs complete integrated research plans for bulk transcriptomics, proteomics, metabolomics, and related omics from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a bulk multi-omics or single-omics-plus-clinical study — including disease-focused, mechanism-focused, biomarker-focused, stratification-oriented, or translational projects. It should define the research question, choose the best-fit study pattern, recommend example datasets as reference candidates only, specify the core analysis modules and method choices, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, cohort availability, assay coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

Designs primary, secondary, and exploratory endpoints for biomedical and clinical research protocols. Always use this skill when a user needs to translate study aims into operational endpoint definitions with event rules, assessment timing, composite logic, interpretability, and protocol-stage auditability. Focus on endpoint precision, feasibility, clinical meaning, ambiguity reduction, and implementation readiness rather than generic study design advice.

Generates complete process-related diagnostic biomarker bioinformatics research designs from a user-provided disease context, gene-family or pathway theme, and validation direction. Use when a study centers on process-related genes, DEG and WGCNA integration, machine-learning feature selection, nomogram-based diagnostic modeling, immune infiltration, regulatory-network analysis, and optional external or experimental validation. Covers five study patterns (process-DEG discovery, co-expression-module integration, machine-learning biomarker selection, diagnostic model/nomogram workflow, immune-regulatory interpretation and validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

Generates complete two-sample Mendelian randomization research designs from a user-provided outcome, exposure or exposure family, and robustness direction. Use when a study centers on summary-statistics causal inference with instrument selection, harmonization, IVW-primary estimation, complementary estimators, sensitivity analyses, optional multivariable upgrades, and conservative evidence interpretation. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

Data structure for annotated matrices in single-cell analysis; use when reading/writing .h5ad (or zarr) and exchanging data with the scverse ecosystem.

Supabase database operations including queries, CRUD operations, RLS policies, and PostgreSQL functions. Use when querying tables, managing data, implementing RLS, or writing database functions.

Troubleshoot common Supabase issues including auth errors, RLS policies, connection problems, and performance. Use when debugging Supabase issues, fixing errors, or optimizing performance.

Supabase CLI commands for local development, migrations, project management, and deployment. Use when working with Supabase CLI, starting local dev, managing migrations, or deploying changes.

Setup and manage Supabase authentication including project connection, tokens, login methods, and user management. Use when configuring Supabase access, implementing authentication, or managing users.

Railway authentication and token management. Use when logging into Railway, creating API tokens, setting up CI/CD authentication, or verifying Railway credentials.

Setup and manage Supabase authentication including project connection, tokens, login methods, and user management. Use when configuring Supabase access, implementing authentication, or managing users.

Use for NVIDIA-related requests where an NVIDIA skill might help, even if the user did not ask for a skill. Trigger on NVIDIA products, hardware, software, SDKs, GPUs, Jetson/JetPack/L4T/BSP/SDK Manager/driver/flashing/setup, CUDA, NIM, NeMo, Omniverse/OpenUSD/SimReady, Isaac, RAPIDS/cuDF, cuPyNumeric, cuOpt, Dynamo, Holoscan, TensorRT, DeepStream, VSS, TAO, NGC/NVCF. Do not use for generic non-NVIDIA route, optimize, deploy, AI, video, data, or infrastructure tasks.

Operate, inspect, maintain, back up, restore, and safely evolve Proxmox VE 9 nodes, storage, networking, LXC, and VMs using official-first guidance. Use for Proxmox node administration, guest lifecycle, storage, network, package updates, backup/restore, upgrade planning, API/CLI inspection, and third-party helper-script review.

Audita un proyecto EXISTENTE (con código + docs) y produce un mapa navegable (PROJECT-MAP.md + MODULES-MATRIX.md + TECH-DEBT.md + STARTER-KIT-PLAN.md). Detecta stack, topología, módulos, capabilities, conventions. NO ejecuta /pm-bootstrap (greenfield). Use cuando Chris dice: '/project-audit', 'auditá el proyecto', 'mapeá esto', 'qué tenemos acá', 'analiza el repo', 'adopta este código al método Luana', 'baseline del proyecto'.

Use when building data-heavy screens, analytics dashboards, metric visualizations, or inline charts for Copilot. Creates bar/line charts, renders data tables, aggregates KPI metrics, builds filterable dashboard layouts, and generates HTML previews for concept validation. Triggers: 'dashboard', 'métricas', 'gráfico', 'chart', 'visualización', 'analytics', 'KPI', 'reporte', 'muestra los datos', 'cómo van los números'.

Creates and manages ManyChat messaging flows, syncs subscribers, configures webhooks, manages tags and custom fields, and triggers flows via API within Nicolify's connections module. Use when the user asks about ManyChat integration, chatbot automation, subscriber sync, webhook setup, or managing messaging flows in ManyChat. Trigger terms: 'manychat', 'many chat', 'chatbot automation', 'subscriber sync', 'messaging flow', 'send content API', 'manychat webhook', 'manychat tag', 'manychat custom field', 'trigger flow'.

Build, modify, and debug tscircuit (React/TypeScript) PCB designs. Use when working with tsci CLI (init/dev/search/add/import/build/export/snapshot/push), choosing footprints, placing parts, wiring nets/traces, or preparing fabrication outputs (Gerbers/BOM/PnP).

Use when Replicator needs off-the-shelf STEP parts for screws, bearings, motors, servos, connectors, boards, rails, or other purchasable CAD components before creating placeholder geometry.

Use when electronic components must be selected, priced, checked for stock, compared with alternatives, or prepared as BOM-ready candidates with datasheet-backed implementation evidence.