Use when doing upstream market-research methodology — sizing a market as TAM/SAM/SOM computed BOTH top-down and bottoms-up (never a single unsourced number), planning a survey sample size with finite-population correction and per-segment minimums, or scoring candidate market segments against Kotler's measurable/substantial/accessible/differentiable/actionable criteria. Outputs always show the method and the assumptions. For market-research analysts and product-marketing at the sizing/survey/segmentation moment. Distinct from marketing-skill (campaign analytics, attribution, demand-gen) — this is the evidence-building methodology, not live-campaign optimization.

Use when a user wants to convert any markdown file in their Claude project into a single-file, lightly-interactive HTML — long-form documents (specs, plans, RFCs, reports, explainers), code reviews with diffs and severity-tagged annotations, or slide decks. Triggers on "convert this markdown to HTML", "make this an HTML file", "turn this into an interactive document", "render this report as HTML", "PR writeup as HTML", "slides from this markdown". Forks context to route to one of three converter sub-skills (md-document, md-review, md-slides) based on a deterministic doctype classifier, after the user has run the design-system onboarding once. Refuses if input is under 100 lines (per Shihipar — markdown still wins below the threshold) or design-system isn't onboarded. Distinct from Anthropic's official Playground plugin (which is interactive prompt-tuning controls with sliders/knobs/prompt-copy-back) and from marketing/landing/ (which is a landing-page generator).

Designs complete single-cell research plans from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a single-cell study — including disease-focused, mechanism-focused, biomarker-focused, translational, perturbation-inspired, or validation-aware projects. It should define the research question, choose the best-fit study pattern, recommend sample grouping logic, suggest reference datasets as examples only, specify the core analysis modules, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, sample metadata, accession numbers, cohort availability, cell-type labels, external validation resources, or literature references. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

M&A strategy for acquiring companies or being acquired. Due diligence, valuation, integration, and deal structure. Use when evaluating acquisitions, preparing for acquisition, M&A due diligence, integration planning, or deal negotiation.

Start an autonomous experiment loop with user-selected interval (10min, 1h, daily, weekly, monthly). Uses CronCreate for scheduling. Use when the user runs /ar:loop or asks to run an autoresearch experiment continuously on a schedule.

Plans sample size estimation logic, power assumptions, feasibility checks, and fallback enrollment strategies for clinical and translational study protocols.

Manage local SEO for service-area businesses — appliance repair, HVAC, plumbing, cleaning, and any business that serves customers at their location. Use when the user wants to: audit Google Business Profile, generate neighborhood service area pages, check NAP consistency across directories, create LocalBusiness schema, or write review responses. Triggers: 'local SEO', 'Google Business Profile', 'GBP', 'service area page', 'NAP consistency', 'local citations', 'LocalBusiness schema', 'review responses', 'Google Maps ranking'. NOT for national SEO (use seo-audit). NOT for general schema (use schema-markup). NOT for AI answer-engine visibility (use aeo).

Use when building or maintaining a persistent personal knowledge base (second brain) in Obsidian where an LLM incrementally ingests sources, updates entity/concept pages, maintains cross-references, and keeps a synthesis current. Triggers include "second brain", "Obsidian wiki", "personal knowledge management", "ingest this paper/article/book", "build a research wiki", "compound knowledge", "Memex", or whenever the user wants knowledge to accumulate across sessions instead of being re-derived by RAG on every query.

Designs a structured real-world evidence study using EHR, claims, or registry data, with explicit handling of time zero, eligibility windows, exposure definitions, outcome windows, censoring, confounding control, and target-trial-emulation logic. Use this skill when the user needs study-type design and protocol framing for an observational clinical study based on routine-care data. Do not invent database fields, follow-up completeness, linkage, coding validity, or causal identifiability.

Use proactively whenever LLM API costs come up -- or should. Triggers include: 'my AI costs are too high', 'optimize token usage', 'which model should I use', 'LLM spend is out of control', 'implement prompt caching', 'we're about to launch an AI feature', 'build me an AI endpoint'. Don't wait for an explicit cost complaint -- if someone is building an AI feature, designing an LLM endpoint, or choosing between models, cost architecture belongs in the conversation. Apply immediately when any of these are true: a system prompt appears that exceeds a few hundred tokens, all requests are hitting the same model, max_tokens is not set, or no per-feature cost logging exists. NOT for RAG pipeline design (use rag-architect). NOT for improving prompt quality or effectiveness (use senior-prompt-engineer).

Use when someone needs a LinkedIn plan rather than a post — content pillars, positioning for a career change or consulting or thought leadership, a sustainable posting cadence, or a newsletter decision. Triggers on "what should I post about", "how often should I post", "LinkedIn content strategy", "should I start a LinkedIn newsletter", "grow my following", "90-day plan". Validates the positioning brief, sizes the week against real hours and refuses a plan that will not survive week five, and gates a newsletter against eligibility and a six-month cadence commitment.

Use when someone wants to grow an organic LinkedIn presence — a content strategy for a career change or consulting or thought leadership, a rewritten profile or headline, post drafts and hooks, a posting cadence or newsletter plan, connection notes and outreach, a commenting strategy, repurposing an article or talk into posts, or a read on why their reach dropped. Triggers on "grow my LinkedIn", "fix my headline", "write a LinkedIn post", "what should I post about", "LinkedIn strategy", "connection request", "my reach dropped". Forks context to route to one of five sub-skills, and refuses automation, scraping, pods, and bulk DMs before any drafting starts.

Use when someone wants their LinkedIn profile audited or rewritten — headline, About section, experience bullets, Featured, banner, recommendations — or says "fix my headline", "my profile gets views but nothing happens", "optimize my LinkedIn profile", "what should my About section say". Scores the headline on five dimensions, audits the whole profile 0-100 and ranks fixes by points per hour, and assembles an About section that survives the "…see more" fold.

Use when someone wants to grow reach through comments, replies, groups, or outreach on LinkedIn — a commenting roster, a connection request note, a DM or InMail, a networking plan, or a check on whether their outreach volume is safe. Triggers on "who should I engage with", "write a connection request", "cold DM", "LinkedIn outreach", "networking strategy", "how many invites can I send". Builds a weekly comment roster inside a real time budget, assembles one message at a time and refuses templates, and caps volume against LinkedIn's limits. Nothing is ever sent.

Use when someone wants to write, edit, or lint a LinkedIn post — a story, how-to, opinion piece, carousel script, video script, or poll — or wants an article, talk, or transcript repurposed into posts. Triggers on "write a LinkedIn post", "is this hook any good", "review my post", "turn this into LinkedIn posts", "carousel", "what format should this be". Lints posts 0-100 on mechanics, hook, integrity, and accessibility; picks the format the material actually supports; and splits long sources into standalone units with a reuse ledger.

Designs discovery, modeling, and validation workflows for prognostic biomarkers in biomedical and clinical research. Always use this skill when the user needs a prognostic biomarker study blueprint rather than a diagnostic test protocol, predictive biomarker design, treatment recommendation, or a completed manuscript. Focus on endpoint family, follow-up horizon, time scale, candidate marker strategy, model-building logic, risk stratification framework, and internal/external validation requirements. Do not invent cohort size, event rate, assay readiness, literature support, or validation access.

Use when someone wants to understand their own LinkedIn numbers — which posts worked, why reach dropped, whether a pattern is real, or how to test a hypothesis. Triggers on "why did my reach drop", "what's working on my LinkedIn", "analyze my posts", "do carousels do better for me", "should I test this", "LinkedIn analytics". Reads your own exported post data, reports medians and outlier bands, tests candidate patterns against a permutation null, and sizes a real experiment — refusing to conclude anything below 10 posts.

When the user wants to plan a product launch, feature announcement, or release strategy. Also use when the user mentions 'launch,' 'Product Hunt,' 'feature release,' 'announcement,' 'go-to-market,' 'beta launch,' 'early access,' 'waitlist,' 'product update,' 'GTM plan,' 'launch checklist,' or 'launch momentum.' This skill covers phased launches, channel strategy, and ongoing launch momentum.

Generates complete process-related diagnostic biomarker bioinformatics research designs from a user-provided disease context, gene-family or pathway theme, and validation direction. Use when a study centers on process-related genes, DEG and WGCNA integration, machine-learning feature selection, nomogram-based diagnostic modeling, immune infiltration, regulatory-network analysis, and optional external or experimental validation. Covers five study patterns (process-DEG discovery, co-expression-module integration, machine-learning biomarker selection, diagnostic model/nomogram workflow, immune-regulatory interpretation and validation) and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

Generates a premium single-page HTML landing page with 3D CSS animations, GSAP scroll effects, and mouse-parallax depth. Forcing intake (product + elevator pitch, audience register, brand overrides, tone) locks down positioning before any copy or markup is written, so the page reflects the actual product rather than generic boilerplate. Use whenever the user says 'landing for X', 'create a landing page', 'build a landing page', 'make a landing page for X', 'I need a web page for Y', or provides product/service details and wants a polished website. Also triggers on 'promotional page', 'product page', 'one-pager', 'web presence', 'sales page'. Outputs a single self-contained HTML file (Claude Code) or HTML artifact (Claude.ai). Supports configurable brand colors via CSS custom property overrides.